| Title | [Effects of Tankejing dry powder inhaler on the inflammatory damage in the lungs of mice infected by FM1] | | Author(s) | Jiang YN, Mo HY | | Institution | Guangdong Food and Drug Vocational College, Guangzhou 510520, China. | | Source | Zhong Yao Cai 2009 Jul; 32(7):1093-7. | | Abstract | OBJECTIVE: To study the effect of Tankejing Dry Powder inhaler on inflammatory in lung injury of mice infected by influenza virus (FM1).
METHODS: Model mice infected by influenza virus FM1 were randomly divided into six groups: the nomal group, model group, low dose, medium dose and high dose of Tankejing Dry Powder inhaler group,and Ribavirin group. The following indices including the change of NF-kappaB in lung tissue at 24 h, the changes of TNF-alpha, IL-1beta, IL-6 in lung tissue, the lung index and the death rate were observed.
RESULTS: Compared with model group, medium and high dosages of Tankejing Dry Powder inhaler could modulate the expression of NF-kappaB, reduce the level of TNF-alpha, IL-beta, IL-6 in lung tissue (P < 0.05), and reduce the lung index and the death number of animals within 14 days (P < 0.05).
CONCLUSION: Tankejing Dry Powder inhaler may reduce the inflammatory injury caused by influenza virus FM1 through regulating the expression level of NF-kappaB and cytokine. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19873739 |
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